| A Novel Connection Between DNA Methylation and Cancer Identified Methylation of the N5 of cytosine (5-methylcytosine) is an epigenetic mark regulating genome function, but methylation of the N3 position is potentially mutagenic. Multiple mechanisms exist to repair this type of DNA lesion...more. Histone Binding Protein Regulates Gene Activation After Mitosis During mitosis, chromatin is compacted into a transcriptional silent state, but after cell division, genes are reactivated to their pre-mitotic pattern in a process termed “gene bookmarking.” A recent study conducted at...more. New Role for Histone Demethylase Identified in Mechanism of Circadian Rhythm Regulation A study conducted at the Salk Institute into the mechanism regulating circadian rhythms has identified a new role for the histone demethylase JARID1a. Circadian rhythms, which...more. |