Active Motif and Epigenetics

Active Motif is a leader in providing high-quality antibodies and assays for chromatin biology, transcriptional regulation, DNA methylation and cellular biology to help researchers in their quest to elucidate the function, regulation and interactions of the genes, their encoded proteins and the epigenetic mechanisms involved.
To download a copy of our new Histone Analysis Brochure, please click here.

Novel Peptide Array for Histone Modifications

The MODified™ Histone Peptide Array makes it easier to screen for interactions with histones. The array contains 384 different histone modification combinations, comprised of 59 post-translational modifications for acetylation, methylation, phosphorylation and citrullination on the N-terminal tails of histones H2A, H2B, H3 and H4. To learn more and see the entire array content, click here.

Recombinant Histones for functional assays

Active Motif is the first company to offer recombinant methylated histones with site- and degree-specificity as well as recombinant acetylated histones for use in functional assays, or to assemble your own chromatin. To see our full listing, click here.

Additionally, Active Motif offers recombinant histone methyltransferases, demethylases and acetyltransferase proteins

Histone FP Binding Assays

The HiLite™ Histone H3 Methyl-Lys9 / Lys27 FP Binding Assay uses fluorescence polarization to identify proteins that interact with histone H3 methylated at either lysine 9 or lysine 27, and to further characterize the interactions. To see how it works, click here.

ChIP Validated Histone and Histone Modification Antibodies

Active Motif offers an extensive line of antibodies to histones and biologically relevant histone modifications. Each antibody has been rigorously tested and validated for use in applications such as IF, WB and ChIP. To see our complete list of histone antibodies, click here.